Sheik Umar Khan, the doctor leading Sierra Leone’s fight against the worst Ebola outbreak on record died from the virus on Tuesday, the country’s chief medical officer said.

The death of  Khan, who was credited with treating more than 100 patients, follows the deaths of dozens of local health workers and the infection of two American medics in neighbouring Liberia, highlighting the dangers faced by staff trying to halt the disease’s spread across West Africa.

Ebola is believed to have killed 672 people in Guinea, Liberia and Sierra Leone since the outbreak began in February, according to the World Health Organisation. The contagious disease, which has no known cure, has symptoms that include vomiting, diarrhoea and internal and external bleeding.

Sheik Umaru Khan: killed by Ebola virus

The 39-year-old Khan, hailed as a “national hero” by the Health Ministry, had been moved to a treatment ward run by the medical charity Medecins Sans Frontieres in the far north of Sierra Leone.

He died on Tuesday afternoon, less than a week after his diagnosis was announced, and on the same day that President Ernest Bai Koroma was due to visit his treatment centre in the northeastern town of Kailahun.

“It is a big and irreparable loss to Sierra Leone as he was the only specialist the country had in viral haemorrhagic fevers,” said the chief medical officer, Brima Kargbo.

Weak health systems are struggling to contain the disease despite international help ranging from doctors to safety equipment.

The West African airline Asky has suspended flights to and from Sierra Leone and Liberia as concern over the spread of the virus has increased since the first death was reported last week in Nigeria’s coastal city of Lagos, home to 21 million people.

Togo-based Asky said it would no longer take on food in Guinea, where the outbreak was first identified. It said that passengers leaving the Guinean capital Conakry would be checked for signs of the disease before departure.

The airline added that medical teams would be deployed to screen passengers in transit through its Lome hub. The victim was a Liberian who travelled to Nigeria on Asky via Lome.

Nigeria’s largest carrier, Arik Air, has suspended flights to Liberia and Sierra Leone because of the Ebola risk.